Synthesis and antibacterial activity of Benzo-2-phenyl-1-thia-2, 3-diazolium bromide and its derivatives

Abstract

We have synthesized a series of sulfenyl derivatives of o-mercapto compound where S(II) atom is electrophilic in nature. The antibacterial activity of five sulfenyl derivatives of o-mercapto compound was studied against three pathogenic bacteria viz. Escherichia coli, Klebsiella, Staphylococus aureus and two nonpathogenic bacteria viz. lactobacillus casei, bacillus cereus by disk diffusion method. Amongst these sulfenyl compounds, three have distinct inhibitory properties against four strains of bacteria except bacillus cereus. The antibacterial activity of these sulfenyl compounds against lactobacillus casei was found to be more compared to the standard ceftriaxone, but was less against pathogenic bacterial strains. Benzo-2-phenyl-1-thia-2,3-diazolium bromide was found to have the high est activity against all bacterial strains. These sulfenyl compounds show cidal action against all tested bacterial strains. Further density functional studies (DFT) were performed to observe stability of BTD-salt and corresponding open structures.